How Clomid Works in Men

April 28th, 2010 § 934 comments

With the suspension of Cincinnati Reds pitcher Edinson Volquez for performance enhancing drug use and a swirl of rumors that the agent involved was clomiphene (also known as Clomid,) I thought it timely to write about how clomiphene works and how it’s used. From what I read on the internets, there is an enormous amount of misinformation floating around out there.

To understand how clomiphene works, you need to know how the pituitary controls the making of testosterone in the testis. Testosterone is made by Leydig cells in the testis, which I explained in my last post. The pituitary releases a hormone called luteinizing hormone (“LH”) that stimulates the Leydig cells to make testosterone. Testosterone is converted to the female hormone estrogen, (which I also explained in my last post,) and estrogen tells the pituitary to stop making more LH. This kind of negative feedback system is common when it comes to how hormones work. It’s just like a thermostat and heater. As the room gets warmer, the thermostat sends less electricity to the heater. When the room gets colder, the thermostat sends more electricity to the heater.

LH testosterone.png

Clomiphene works by blocking estrogen at the pituitary. The pituitary sees less estrogen, and makes more LH. More LH means that the Leydig cells in the testis make more testosterone.

As I explained in my last post, giving testosterone to a man does just the opposite. The pituitary thinks that the testis is making plenty of testosterone, and LH falls. As a result, the testis stops making testosterone, and the usually high levels of testosterone in the testis fall to the lower level in the blood.

So clomiphene is a way to increase testosterone in the blood and the testis at the same time. It preserves testis size and function while increasing blood testosterone.

Unfortunately, clomiphene is not FDA approved for use in the male. Like most of the medications that we use to treat male fertility, the pharmaceutical company that originally sought approval by the FDA did it for women. Clomiphene is now generic, and it’s unlikely that anyone will pony up the hundreds of millions of dollars necessary to get it approved for the male. That’s the bad news. The good news is that it means that this medication is fairly inexpensive, cheaper than most forms of prescription testosterone. Can a doctor prescribe clomiphene for a man? Yes. It’s “off label”, meaning that it’s not FDA approved for use in men.

As a medication, clomiphene is usually well tolerated by men. In my experience, most patients don’t feel anything as their testosterone rises. Those that do feel an increase in energy, sex drive, and muscle mass, especially if they work out. Very rarely I’ve had patients report that they feel too aggressive, or too angry. Very very rarely (twice in the last 20 years) I’ve had patients report visual changes. That’s worrisome, as the pituitary is near the optic nerve in the brain, and visual changes suggests that the pituitary may be changing in size. Because the skull is a closed space, it’s alarming if anything in the brain changes in size. In the last twenty years, I’ve also had two patients who had breast enlargement (called “gynecomastia”) while using clomiphene. Needless to say, for any of these problematic side effects, the clomiphene is discontinued.

So that’s the story with clomiphene. It can be used in the male, either for fertility or low testosterone levels. It’s an off label prescription drug. It works, and is usually well tolerated by men who take it.

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§ 934 Responses to How Clomid Works in Men"

  • maxneo says:

    Hi Doctor, thanks for the information. What are the withdrawl symptoms of Clomiphene. Will it lower the testosterone drastically? I read in an article that sudden lowering of testosterone causes andropause, hot flashes and headaches.

    • maledoc says:

      The “withdrawl symptoms” would depend on the response of the individual patient. Such a patient should really be seeing, treated and monitored by a physician familiar with male endocrine therapy.

    • Steve says:

      Hi Doctor,

      What is the duration of treatment when using clomiphene citrate to treat male secondary hypogonadism? I guess what I’m trying to get at is if clomid is a quick fix or if one has to stay on it for the rest of their lives to maintain normal testosterone levels.

      Thanks!

  • Andy says:

    Hi Doc,

    Overall, I’m very enthusiastic about Clomid.
    I’ve been taking it for about 2 years. It has significantly increased my alertness and energy. I started exercising and lost 20 lbs while gaining muscle mass.

    One Concern: I do have some visual side effects. When going from darkness to light, such as a movie theatre to outdoor sunlight, I see what I would describe as trails. My moving hand looks like 10 fingers instead of 5. The effect goes away within a minute or two. Is this the kind of disturbance you referred to?

    Thanks

    • maledoc says:

      Andy, you need to ask the physician that prescribed the medication for you about your side effects.

    • Hankat says:

      Andy, I have exactly the same visual effect as you describe it, when moving my arm I see the siluet of another hand following it. Usually when going from darkness to light. I have been taking clomid for 6 months. However, I went to the ophthalmologist, and he said this is not the clomid, but the retina becoming thinner due to myopia, and the gel covering the retina falling out. After reading your post I have my doubts, since you are also getting clomid. Let’s find out what is causing this!!
      Regards

  • fred says:

    can I take clomiphene and a reasonable dose of dhea together.

  • Zika says:

    Hello Doc,

    The question is, if use of Clomid can damage male potency and libido?

  • BHubs says:

    My husband takes this as prescribed by his doctor to help with his Low Testosterone and low libido.

    Now, I am pregnant and I read that a woman taking Clomid up to 2 months before conceiving can cause birth defects. I was wondering if the same goes for the male? Since my husband was on Clomid when we conceived, can that cause birth defects?
    Additionally, if the male was on Clomid can that still increase the chances for multiple births as it can in women?

    • maledoc says:

      Congratulations on your pregnancy, Brandie! I’m sorry, but I can’t answer personal questions about your husband’s health. Please read the FAQ.

  • linda jones says:

    we have been trying to conceive for 2 yeara now. they put my husband on clomid because of his low sperm count, do you know how long it takes for the clomid to actually start increasing the sperm?

  • Miles says:

    Has there been evidence to demonstrate that a male taking clomid for for a period of many months or years might experience an attenuation of endogenous LH production from the pituitary?

    Also, is there evidence to suggest that clomid can increase risk of prostate or testicular cancer?

    • maledoc says:

      Hi Miles, great questions all. One of the problems with an application for a drug that has not gone through the FDA approval process like clomiphene for the male is that we don’t have the data to address the concerns you raise. In my experience, I haven’t observed attenuation of endogenous LH, but that doesn’t mean that it can’t happen. Likewise with increasing the risk of testis cancer: I haven’t observed a link, but that doesn’t mean that it isn’t there. Prostate cancer could be an issue, as the tumors are slow growing and many aren’t evident for many years before they are detected. The majority of those involved in the field believe that testosterone doesn’t initiate but may promote androgen sensitive tumors. That’s why we assess PSA regularly for men who are taking testosterone directly or medications that increase its production.

  • michael says:

    good article on clomiphene. Was wondering why some men do not get much of a response from clomid and others do, are there any easily identifiable reasons? I have read many threads about some guys saying it raised T it alot and other guys saying they got little response to clomiphene. Look forward to hearinf from you

    • maledoc says:

      It’s a really good question, Michael, and one that can’t be answered at this point. The expectation is that some men’s pituitaries respond differently to stimulation with various kinds of agents, but the biology of how that works is yet to be understood.

  • vic says:

    Does clomid increase sperm level .

    • maledoc says:

      Hi Vic, I’m not sure what you mean by “sperm level”. Testosterone is a primary driver of the sperm factory, and in some men whose testosterone is low, clomiphene may increase the activity of the sperm factory.

  • ASHWIN says:

    Hello doctor,i would like to know whether my sperm concentration will increase when taking Clomid. My sperm concentration is only 9%.

  • James says:

    As Clomid causes an increase testosterone, would it also cause an increase in dihydrotestosterone (ie would it increase the risk of losing hair?)
    Thanks Maledoc.

  • Grant says:

    In your experience, when using Clomiphene for male infertility, what have been the ranges of increased sperm count and motility that you have encountered? What kind of increase would be considered a best case scenario result? Do you have any specific examples of where any patients levels were before and after use?

    Thanks in advance for your reply.

    • maledoc says:

      It’s variable, depending on the individual man’s testosterone level and semen analysis. A best case scenario is a pregnancy πŸ™‚

  • miss p says:

    Hi Doc,

    What are the long term side effects of clomid for men? and if a man an woman take clomid together does it increase possibility of a muliple birth? also is it ttue that clomis caused birth defects?

    • maledoc says:

      We don’t have good data on long term effects of many drugs, including clomiphene, which is one of the reasons why a man needs to be monitored by his doctor while taking the medication. I don’t know of any data pointing to a man taking clomiphene and multiple births or birth defects, and it doesn’t make sense to me that they would be related.

  • Patrick says:

    I apoligize if you’e answered this before, but
    I’m wondering if clomid will cause elevated estrogen in men as a direct result
    of the elevated testosterone.

    That is, does clomid just “trick” the pituitary into thinking estrogen is low or does it actually reduce the level in the blood? If the former, is it advisable (or at least, conceivable) to ever add an aromatase inhibitor to a clomid regime? Would this potentially give clomid treatment a synergistic boost by causing more testosterone production while also prevernting its conversion into estrogen?

    Thanks for your time.

    • maledoc says:

      As testosterone rises and clomiphene does not affect aromatase, the enzyme that turns testosterone into estrogen, estrogen levels should rise and often do. However, in my experience, that rise is variable for individual men. If the estradiol does rise, adding the aromatase inhibitor anastrozole would theoretically make sense, but then again, theoretically you should get nearly the same response from anastrozole alone. Typically if a man’s estrogen rises too much on clomiphene, I discuss changing to anastrozole alone.

  • Patrick says:

    Is the test for estradiol accurate and reliable when a man is on long-term clomid therapy? IÒ€ℒve read that it isnÒ€ℒt.

  • Jamit Singh says:

    hi sir if LH is low normal and testosterone is low normal should clomiphene be use

  • Sam says:

    Since drugs like sustanon can lead to low sperm count during its cycle, is it advisable to combine it with clomid?

  • Rob says:

    I saw that one side effect can cause enlarged breasts on a male. The whole reason i was researching this product was cause i wanted to shrink my chest sincei have what they consider “man-boobs”. How can raising test and lowering estrogen actually enlarge your breasts? By the end of this article i was so let down.

    • maledoc says:

      Hi Rob, I’m sorry, but I can’t answer personal questions about your own health. Please read the FAQ. You’d really benefit from seeing a doctor who can care for you individually.

  • Quig says:

    Hi Dr, how Likely or what are the odds of someone getting pregnant off a man using clomid where the fertility issue is due to the males sperm with the count or mobility and how long might it take.

    • maledoc says:

      It really depends on the specific case. If the production of testosterone is low in the testis, it can affect sperm, and clomiphene would then be sensible treatment.

      • venkatesh says:

        hi dr..
        i have variation in sperm count..some times it seem 20 million and some time 5 milliion.
        but motility is 5%..is clome 25mg can resolve the problem…because my doctor prescribed 25mg ..iit is enough

    • Quig says:

      Is the low testrone the main reason for low sperm or what might low testrone mean, and also I read this blog about vitman C what impact might that have

      • maledoc says:

        As I explained, it really depends on the specific case. If the production of testosterone is low in the testis, it can affect sperm. As for vitamin C, if severely deficient, health suffers, and when health suffers, so does the making of sperm.

  • Scott37 says:

    I have seen several reports and studies stating that SERMs such as Clomid and Nolvadex can inhibit HGH and therefore IGF-1 production. Have you heard this or witnessed it in blood tests of your patients?

    • maledoc says:

      There is a torrent of basic science reported in the literature regarding endocrine interactions of steroid hormones and agents which modulate those hormones. What is clinically relevant is a trickle, and there isn’t yet a clear relationship between agents which change pituitary release of LH and GH in the human male. It might be there, it just isn’t clear if it is.

  • SteroidsForU says:

    (Do not take my word for any of these i am not a guru but just stating research)

    For all you wondering, clomid and nolvadex are two components that are closely debated for a pct.

    Clomid is much faster at getting your testicles to produce testosterone again but Nolva is better for treating gyno issues.
    Both will boost your testosterone production, and nolvadex has been proven to be slightly superior than clomid.
    One of the first drugs we?ll consider for this purpose is what is typically called a SERM. Nolvadex (Tamoxifen) is a SERM (Selective Estrogen Receptor Modulator, which means that it has the ability to act as an anti-estrogen with regard to certain genes, yet also acting as an estrogen with respect to others.

    That?s the ?selective? part I guess. It does this by blocking gene transcription in some cases, and initiating gene transcription in others (3). Luckily for us, it has estrogenic effects on bones (meaning it increases their density), and blood lipids -meaning it lowers cholesterol-, (4)(5)as well as preventing gynocomastia by preventing estrogen gene transcription in breast tissue.

    However, it acts as an anti-estrogen in the pituitary, thus increasing LH and FSH, which results in an increase in testosterone. 20mgs of Nolvadex will raise your testosterone levels about 150% (6)…Nolvadex actually has quite a few applications for the steroid using athlete. First and foremost, it?s most common use is for the prevention of gynocomastia.

    Nolvadex does this by actually competing for the receptor site in breast tissue, and binding to it. Thus, we can safely say that the effect of tamoxifen is through estrogen receptor blockade of breast tissue (7).

    Estrogen is also important for a properly functioning immune system, and not only that, but your lipid profile (both HDL and LDL) should also show marked improvement with administration of tamoxifen (34).

    Nolvadex also has some important features for the steroid using athlete. In hypogonadic and infertile men given nolvadex, increases in the serum levels of LH, FSH, and most importantly, testosterone were all observed (35)It can also block a bit of estrogen in the pituitary, which is a great benefit when used with HCG (more on that later) (36)(37).

    The increase in testosterone Nolvadex can give someone with a dysfunctional is basically that 20mgs of Nolvadex will raise your testosterone levels about 150% (6)…Why don?t we use Clomid, another SERM? Well, basically because it takes much more to do the same thing.

    In comparison, it would require 150mgs of Clomid to accomplish that type of elevation in testosterone, but Nolvadex also has the added benefit of significantly increasing the LH (Leutenizing Hormone) response to LHRH (LH-releasing hormone) (6). This most likely indicates some kind of upregulation of the LH-receptors due to the anti-estrogenic effect Nolvadex has at the pituitary.

    Although both Nolvadex and Clomid are both SERMs, they are actually quite different. As you already know, Nolvadex is highly anti-estrogenic at the hypothalamus and pituitary, while Clomid exhibits weak estrogenic activity at the pituitary (7), which as you can guess, is less than ideal. It should be avoided for the PCT I?m suggesting?and in fact, avoided in general?it?s simply not as good as Nolvadex.

    Need I even add that the 150mgs of Clomid you need to get the hormonal increase experienced with 20mgs of Nolvadex is much more expensive? So lets dump the Clomid?and no, using it along with Nolvadex will provide no ?synergy? that I?ve ever seen in any relevant study.

    SO how much Nolvadex should you use during PCT? I favor using 20mgs.day, although to be totally honest, you can probably even get away with far less than that.

    Doses as low as 5mgs/day have proven to be as effective as 20mgs/day for certain areas of gonadal stimulation. (8) 20mgs/day, however, is a dose that myself and others have used with great success, and the research I?ve done in this area typically uses this milligram amount. SO lets stick with 20mgs/day for now.

    So that effectively suggests Nolvadex can not be used at Mega-doses to get a mega-increase in your natural hormones.

    We can?t use huge doses of any Anti-Estrogen, actually, and expect huge increases in our natural hormones, actually. Arimidex (an Aromatase Inhibitor ?which means it stops the conversion of testosterone into estrogen-another drug used to fight breast cancer like Nolvadex) exhibits basically the same effects when .5mgs or a full 1mg is used (9) and I have even read studies where up to 10mgs/day of Arimidex is studied with no clear benefit over 1mg/day.

    Letrozole (another Aromatase Inhibitor) is capable of inhibiting Aromatase maximally at a mere 100mcg/day (10.). So clearly we need to add in other compounds to our PCT, because Mega-Doses of one compound will not I think it?s absurdly funny to see people recommending upwards 40-80mgs/day of Nolvadex, or a full milligram (or two!) of Arimidex, in their post-cycle or on-cycle suggestions.

    • maledoc says:

      I appreciate your interest and enthusiasm, but don’t quite agree with much of your argument. In my reading of the literature, clomiphene citrate has been investigated in more studies than tamoxifen, and studies of both unfortunately suffer from a lack of placebo-controlled, double blind design. As for estradiol, it’s dependent on aromatase activity, and should increase whenever testosterone does unless an inhibitor of aromatase is involved. But thanks for reading and expressing your opinions.

  • Farhan says:

    Sir can i use Dutasteride with clomid?as i dnt want hairloss..so is it safe to use dutasteride with clomid?

  • AUON ABBAS says:

    Can Clomid used as after steroids cycle as a post cycle therapy . ? if so what is the recommended dosage after the use of deca durabolin.

    • maledoc says:

      I’m not sure what you mean by ‘cycle’ as that isn’t a common term used to describe the use of medication in the male. If you’re referring to the use of anabolic steroids for increasing muscle mass in the absence of deficiency or disease, I’ll not comment on that as it isn’t a therapeutic use. Please read the FAQ.

  • Lew Ayotte says:

    I just started taking Clomid last week, perscribed by my doctor to increase my low sperm count (17million). I’ve heard that your sperm count is actually affected by whatever happened 3 months ago (e.g. if you had a cold 3 months ago your sperm count could be lower today). So, my question is, how long does Clomid take to work? Meaning, does it normally take ~3 months before you see an improved sperm count?

    Thank you!

  • Chris says:

    Hey Doc,

    Men who are diagnosed with low natural testosterone may be prescribed drugs (e.g. testosterone cypionate) to help bring the testosterone back to a ‘normal’ level. I don’t believe that the test. cyp. is considered natural as in what your body produces.

    Based on what you wrote about Clomiphene, it seems to trick/mimic your body into producing its own natural supply. Even though any drug has its pros and cons, do you feel it is better for the body to produce its own supply through the use of a drug such as Clomiphene rather that using IM test. cyp.?

    Thanks.

    • maledoc says:

      Hi Chris, the difference between giving a man testosterone directly versus how clomiphene citrate is what this post is all about πŸ™‚

  • Toni says:

    God bless you doc! Im secondary hypo, and have never used steroids. Having read a whole bunch of stuff on your website, I tried in vain to get my doctors/endos here in the UK to prescribe clomid to me as a first attempt to kickstart my pituitary. They just would not do it no matter what, and the standard reponse was to prescribe testosterone gel along with its long term side effects.

    Rightly or wrongly, I acquired clomid pills, and took 25mg a day for 4 weeks, followed by 25mg every other day for 3 weeks, followed by 12.5mg every other day for 3 weeks. IMPORTANT – whilst taking clomid, generally felt better although libido went to zero. since stopping clomid 3-4 weeks ago, I feel fantastic! libido has returned, feel better in general, no ED. Im going for a blood test in 3 days time to check my levels.

    I have provided my dosing so that maybe it will help in your further research. Again, god bless you doc.

  • Dave says:

    How long can guys be on clomid?can someone be on clomid for 3the years straight?

    • maledoc says:

      Hi Dave, we don’t formally know as we don’t have long term studies. It can be used long term, but the man should be monitored by his physician.

  • olive says:

    Hi doc, is it okay for a man and woman to start using clomid at the same time?

    And should he use it with vitamin E or C? Your answer will be appreciated Thanx.

    • maledoc says:

      If a woman has a problem with ovulation and a man has a problem with testosterone, then clomiphene may be prescribed for both at the same time. There is no interaction with vitamins.

  • Patrick says:

    Thank you in advance for your time. This has been a great resource. Are there known complications/concerns for using Clomid while using Enbrel?

  • rose says:

    can clomid help in sertoli cell only syndrome

    • maledoc says:

      That’s a great question, Rose. In complete Sertoli cell only syndrome, where there are no sperm cells at any stage of development in the entire testis. The problem is, it’s impossible to know whether there are any sperm cells in the entire testis without microsurgical testis exploration. It’s been shown that a single (or few) biopsy(ies) may often miss a small area of the testis where sperm are developing, and in our studies, clomiphene increases the production of sperm in those instances.

  • Mel says:

    Just to clarify, if there are no Leydig cells found in the testes then obviously Clomid will not foster new sperm regeneration?

    • maledoc says:

      If there are no Leydig cells in the testis, it isn’t a testis. There are cases where sperm cells aren’t found in the testis, but Leydig cells would remain. They may not function well, but they’d be there.

  • Scott37 says:

    Do you always discontinue a patients clomid if they experience visual side effects?
    If you discontinue Clomid what other treatment could raise testosterone and protect/maintain fertility?

  • John Lee says:

    Hey Doc, does Nolvadex have the same effect as Clomid as far as male’s for blocking estrogen before it goes back to the Pituitary?

    • maledoc says:

      Hi John, how tamoxifen (Nolvadex) works is very similar to clomiphene. There’s just more studies in the literature on clomiphene in men.

  • venkatesh says:

    wha tis the gud tablket to increae sperm count and active motile/…

  • Zak says:

    Doc,
    for those patiants whom already had a testicular cancer (seminoma) and went through operation to remove one testis, then post treatment with chemo (BEP 5 cycls).
    is it recorded that clomid help in inatiating the existing testis to produce sperum?
    and what was the longest period after stopping chemo to start producing sperums?

    • maledoc says:

      It depends on whether the man has low testosterone. If so, and his pituitary isn’t already generating a large amount of luteinizing hormone, then it may be useful.

  • Sam says:

    Dear Sir, Its there a bill I can take,make my testicles bigger?

  • Jules says:

    Doc,
    Do you know of any instances where clomid has “kick” started spermatocyte maturation in an individual diagnosed with Maturation Arrest resulting in Azoospermia?

  • Perry says:

    I hope this question hasn’t already been asked/answered, but as Clomid has both agonist and antagonist properties in estrogen reactive cells, are you able to tell a person which cells experience notable promotion and negation of estrogen’s effects, respectively?

    Also, if Clomid is used as a preventative tx for gynomastia in bodybuilders, how is it that a rare patient will experience this symptom? Would I be correct in assuming that increased testosterone is aromatized and built up to such a degree that the Clomid’s antagonistic effect is overpowered?

    Generally speaking, can pharmacotherapy be initiated conservatively in a similar manner to Prednisone (a large initial amount and then rapid taper) with the goal of avoiding side effects with lasting results? Or are the benefits lost in short order?

    In your experience treating men with mild hypogonadism-not severe loss of T, infertility or post cycle bodybuilders-what’s been a concurrently safe and successful approach?

    • maledoc says:

      Hi Perry, there’s a lot of assumptions in your post that aren’t quite right. Clomiphene, for example, doesn’t have “both agonist and antagonist properties”: its primary action is as an inhibitor of estrogen in the brain. It doesn’t prevent gynecomastia: if the testosterone increases enough and if aromatase activity is high enough, it can cause gynecomastia. It doesn’t function like prednisone at all, and “cycling” and “tapering” makes little sense. I may be wrong, but it sounds like you might be thinking about using the medication in ways that aren’t for a medical condition such as low testosterone, which I would not recommend.

  • Perry says:

    I am actually curious as to how it would be implemented in the treatment of low testosterone.

    • maledoc says:

      Then I’d recommend that you peruse my entire blog. There’s a number of posts regarding clomiphene’s use in low testosterone.

  • John Lee says:

    Doc, you said that clomid use in men raises testosterone which i understood in your article but would the testosterone levels in your studies stay elevated or would life long use be necessary to maintain the effects of clomids effects?

  • Tanderson says:

    Hello, I was wondering if you have used or would ever consider using Clomid on men following a vasectomy reversal to increase sperm count/motility? If so, was the outcome favorable?

    • maledoc says:

      If the man’s testosterone is low, yes. My own preference is to assess a man’s hormones prior to reversal to see if medical treatment might be needed as well as surgery.

  • Amy Thompson says:

    What are your thoughts about Calcium Channel Blockers (CCB) affecting sperm count? Could Clomid help the sperm count even while taking a CCB or would one have to stop taking CCB for Clomid to work?

    • maledoc says:

      That’s a really great question. There are reports of calcium channel blockers potentially affecting sperm motility in some men, but it is by no means definitive data. My experience has been that they don’t affect sperm very much in most men. See this summary in the Journal of Andrology for some idea of how these drugs may affect sperm in some men.

  • David says:

    Thanks for a very interesting article.

    Is there a relation with testicle size and the effectiveness of clomid in treatment? i.e. men with atrophied testes vs men with full sized testes.

    • maledoc says:

      It depends on if the loss of sperm cells that makes the testis atrophy is due to a problem with the cells making testosterone or not.

  • Anne says:

    Can vitamin C and E be taking with clomid? Can someone take vitamin C and E with clomid? Is it ok for people to take vitamin C and E with clomid?

  • drew says:

    In men, does Clomid raise the SHBG level? If so, by what percentage?

  • David says:

    Thanks for your answer.

    What are the common causes of low sperm count in men with full sized testicles (i.e. non-atrophied)?

    • maledoc says:

      Very many: that’s why a man with a low sperm count and non-atrophied testes should see a doctor πŸ™‚ Keep in mind that sperm counts are highly variable, and a low count could be due to natural variation.

  • Mel says:

    I was just wondering A) if a man and a woman are taking clomid at the same time what percentage do they have in getting pregnant? B) if a man has low morphology but a decent sperm count is clomid a good option or is there another medication that is better suited for this?

    • maledoc says:

      It really depends on the specific man and woman, and why they are taking the medication. I’ve written about morphology in other posts: you may want to peruse this blog πŸ™‚

  • Alex Kennedy says:

    Hi, maledoc I’ve the following concern:
    Since the pituitary regulates the hormones and produces those hormones more that it thinks is less and those hormones less that it thinks is more in the body. Forexample. When men take anabolic steroids their pituitary stops testosterone production thinking that there is already too much in the body. And in the long term doesn’t start producing as much as it used to.

    My question is

    If you use clomid wouldn’t ur pituitary make more estrogen thinking that it’s quantity is low. And after long term use wouldn’t your pituitary get trained for more production and if clomid is discontinued, it would still make more estrogen than before?

    Thanks.

    • maledoc says:

      Hi Alex, the pituitary doesn’t make estrogen. You might want to peruse my blog a little to read how estrogen is made in the male.

  • Sharon says:

    Hi, Dr. Niederberger–

    Thank you for all the valuable info. Would like to know more about clomiphene b/c of Androgel’s negative side effects on my husband. Pharmacists have said that they’ve never filled a script for Clomid for anyone but women. How would a man be able to have it prescribed? Urologist, perhaps?

    Appreciate it very much!

    SC

  • Alex says:

    Hi Doc, If a male start taken clomi, how long would it take for the male to start pruducing more sperm?
    Thanks for your help